Endocrine Abstracts

Background: The best lateralization method to ascertain cure after surgery in unilateral primary aldosteronism (PA) is debated. Risk of persistent of PA in those with non-classical adrenal histopathology remains poorly characterized.Objective: We examined the value of anatomical compared with functional subtyping and the significance of immunohistochemical analysis of CYP11B1 and CYP11B2 for the outcome and histopathological diagnosis of primary aldoster...

Background: The cure of unilateral primary aldosteronism (PA) after adrenalectomy can result in complete, partial or absent biochemical and clinical improvement1. Histological findings from HE samples are of little assistance in determining if adenoma or hyperplastic adrenal tissue is hormonally overactive. Our aim in the present study was to compare immunohistochemical (IHC) CYP11B1 and CYP11B2 staining in adrenal slices to histological diagnosis based on H&E s...

Insulinomas are rare insulin-producing pancreatic neuroendocrine tumours. Most insulinomas are non-metastatic and can be cured by surgery, but in 10% of the patients insulinomas metastasize, which is associated with a significantly impaired overall survival. As the metastatic potential of an insulinoma cannot be reliably predicted with the current biomarkers, we aimed to evaluate the expression of somatostatin receptors (SSTRs) and glucagon-like peptide-1 receptors (GLP-1Rs) i...